Analysis of dopamine receptor and dopamine transporter genes in schizophrenia
نویسندگان
چکیده
منابع مشابه
P139: Role of Dopamine Receptor D3 in Depression and Anxiety
Dopamine (DA) is one of the main catecholamines in the brain and is crucial for movement coordination, endocrine function, reward, mood, memory and emotions. The dopaminergic system is the primary therapeutic target in the treatment of Parkinson’s disease (PD), drug addiction and schizophrenia. Notwithstanding, dysfunction of central dopaminergic neurotransmission has also been associated to de...
متن کاملPhysicochemical properties analysis and dopamine D2 receptor (D2R) docking of zotepine as an atypical antipsychotic antagonist
The main purpose of the present investigation is the study of therapeutically effect of Zotepine in schizophrenia disease treatment. In first step, the molecular structure of the said compound is optimized using density functional theory (DFT) technique by B3LYP functional method at 6-311++G(d,p) level of theory. Then the electronic properties of the title molecule are calculated using frontier...
متن کاملDopamine receptor supersensitivity and schizophrenia: a review.
Advances in knowledge of brain neurochemistry have lent impetus to the biological study of schizophrenia. A prominent example is the dopamine hypothesis. Increasing additions to and refinements of neurochemical knowledge, particularly the study of receptors, have continued to support biological hypotheses of schizophrenia. A recently proposed hypothesis is that schizophrenic patients suffer fro...
متن کاملTargeting the dopamine D2 receptor in schizophrenia.
After a 12-year search for the antipsychotic receptor, the binding site was discovered and labelled by [3H]haloperidol in 1975. Of the various neurotransmitters, dopamine was the most potent in inhibiting the binding of [3H]haloperidol, indicating that the antipsychotic receptor was a dopamine receptor, now named the dopamine D2 receptor, a major targeting site in schizophrenia. All antipsychot...
متن کاملAdditive effects of the dopamine D2 receptor and dopamine transporter genes on the error-related negativity in young children.
The error-related negativity (ERN) is a negative deflection in the event-related potential that occurs approximately 50 ms following the commission of an error at fronto-central electrode sites. Previous models suggest dopamine plays a role in the generation of the ERN. We recorded event-related potentials (ERPs) while 279 children aged 5-7 years completed a simple Go/No-Go task; the ERN was ex...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Okayama Igakkai Zasshi (Journal of Okayama Medical Association)
سال: 1996
ISSN: 0030-1558,1882-4528
DOI: 10.4044/joma1947.108.7-8_253